The administration of contrast media agents is relatively safe and rarely causes systemic toxicity in the course of routine imaging studies. While the incidence of serious toxicity is low, these drugs usually have fatal effects after Central Nervous System (CNS) exposure, when contraindi-cated, routes of administration allowing CNS or spinal cord entry, and in doses that exceed user recommendations. Most patients do not survive overdose effects, and therefore, limited information exists on long-term sequelae following such incidents. We provide evidence for the acute and chronic effects of exposure to contrast media overdose in two patient cases. We report findings from inadvertent overdose following admin-istration of iopamidol and iothalamate resulting in the manifestation of serious and persistent adverse effects. Expertise in assessing adverse drug reaction reports is an essential and required responsibility of drug developers and regulators.

Electronic cigarettes, Electronic Nicotine Delivery Systems, and vaping devices, in general, are safer alternatives compared to conventional burn-down cannabis and tobacco products. This article seeks to elucidate the potential for a more generic form that would be more appropriate for the protecting of public health; electronic drug-delivery systems or EDDS. The technology of electronic cartomizers and nebulizers have been conceptualized, patented, and marketed for nearly a century, yet only recently have electronic cigarettes finally surpassed traditional combustible cigarettes in seeming safety and efficacy for electronic nicotine drug-delivery. Following this line of thought leads to a valuable opportunity in the logical conclusion that if nicotine salts can be consumed en masse via these device technologies, then there exists the potential for multitudes of new therapies delivering generic and novel pharmaceuticals.

AbstractBackground: Amlodipine is an antihypertensive drug used in the management of hypertension and other cardiovascular diseases. Compared to calcium antagonists, β-blockers or ACE inhibitors, amlodipine tolerability showed a significantly lower incidence of side effects. In addition, compared with enalapril, amlodipine significantly reduced non-fatal myocardial infarction and stroke, or transient ischaemic attack.

Aim: Development of a novel bio-analytical method for quantification of amlodipine in plasma and its clinical applications, including safety and tolerability evaluation and bioavailability studies.

Methods: After extraction of amlodipine from plasma, samples were chromatographed with a mobile phase consisting of 25mM Ammonium Formate: Acetonitrile 15:85 V/V with 0.1% Formic acid at flow rate 0.6ml/min, ESI positive mode, and m/z 409.4→238.1, 456.2→354.2 for amlodipine and lacidipine (internal Standard) respectively. The bioequivalence study involved 27 volunteers in a crossover pattern. Pharmacokinetic parameters AUC 0-72, Cmax, and Tmax used for assessment of bioequivalence of the generic and reference products.

Results: The developed bioanalytical method showed that the average recovery of amlodipine from human plasma was 80.166%. The limit of quantitation was 0.1ng/ml, and the correlation coefficient (r2) was equal to 0.999. Analysis of variance showed that there was no significant difference between generic and reference products

Over the last two decades, there has been a growing interest in both regenerative medicine and emotional intelligence. Attention to advance-ments in autologous cell therapies has been overshadowed in recent times with the COVID-19 pandemic, which has compounded emotional stressors affecting health care that came before it. The importance of this connection and the underlying role of stress on the immune system requires further exploration.

This article highlights the role that stress and the immune system have in the healthcare setting and explores how psychology affects the clinical environment. Additionally, it discusses how healthcare workers can leverage emotional intelligence to enhance therapeutic outcomes in their patients and improve overall health status for themselves.

Especially in the past year, there has been a growing interest in the importance of emotional intelligence in managing the compounding effects of the COVID-19 pandemic on both patients and healthcare workers, and this has further underscored the importance of mind-body health management. The growing awareness of emotional intelligence and education on health will undoubtedly shape the next decade of medicine.

The objective of the present study was to formulate a extended release gastro-retentive tablet formulation of ornidazole in order to improve the efficacy of the delivery system in the eradication of Helicobacter pylori infection from the stomach. HPMC K4M and 100M were used as matrix-forming polymers and PVP K30 as binder. Sodium bicarbonate was taken as buoyancy contributor. The floating matrix tablets were prepared by wet-granulation method and 23 full factorial design was adapted taking HPMC K4M , HPMC 100M and NaHCO3 as independent variables. All formulations were evaluated for weight variation, content uniformity, hardness, friability, invitro buoyancy and drug release. The study showed that the tablets remained buoyant in 0.1N HCl over a period of 8 hours and were capable of releasing drug over 8 hour. Analysis of the dissolution data revealed that the kinetic of drug release follows Peppas-Korsemeyer model indicating non-Fickian anomalous diffusion mechanism. ANOVA was done to understand the effect of independent variables on the floating lag time and the cumulative % drug release at 1hr, 2hr, 4hr, 6hr and 8hr using Design-Expert software version 8.1. The study showed that HPMC K4M has more drug- release-retarding capacity than that of HPMC 100M. The formula F8 showed floating lag time of 2 mins and 45% drug release at 8 hours.